Oligonucleotide-, protein and/or peptide-polymer conjugates

Details Oligonucleotide-, protein and/or peptide-polymer conjugates Oligonucleotide-, protein and/or peptide-polymer conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) A61P 31/22 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2684165

A conjugate or compound comprising polyethyleneglycol and an oligonucleotide, wherein at least one polyethyleneglycol is linked to the 5´-end of the oligonucleotide and at least one polyethyleneglycol is linked to the 3´-end of the oligonucleotide, wherein the molecular weight of the polyethyleneglycol linked to the 5´-and 3´-end of the oligonucleotide is identical and is < 5000 Da, or wherein the molecular weight of the polyethyleneglycol linked to the 5´- and 3´-end of the oligonucleotide is different.

L'invention concerne un conjugué ou un composé comprenant du polyéthylèneglycol et un oligonucléotide, dans lequel au moins un polyéthylèneglycol est lié à l'extrémité 5' de l'oligonucléotide et au moins un polyéthylèneglycol est lié à l'extrémité 3' de l'oligonucléotide, les masses moléculaires des polyéthylèneglycols liés aux extrémités 5' et 3' de l'oligonucléotide étant identiques et étant < 5 000 Da, ou les masses moléculaires des polyéthylèneglycols liés aux extrémités 5' et 3' de l'oligonucléotide étant différentes.

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