Oligonucleotide sequences and transgenic animals transfected...

Details Oligonucleotide sequences and transgenic animals transfected... Oligonucleotide sequences and transgenic animals transfected...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2117756

2117756 9321309 PCTABS00027 Clones (SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3) have been isolated and sequenced. An antisense construct has been made from part of SEQ ID NO:1 that blocks opioid binding in cells and has been used to produce transgenic animals having a reduced sensitivity to narcotic analgesics. The oligonucleotide sequence introduced into the animals at an embryonic stage was the first about 500 base pairs, but was reversed in direction. Oligonucleotide constructs of the invention are also useful as probes or as therapeutic and diagnostic agents.

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