Oligonucleotide synthesis with lewis acids as activators

Details Oligonucleotide synthesis with lewis acids as activators Oligonucleotide synthesis with lewis acids as activators

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2376016

A process for synthesizing oligonucleotides by phosphoramidite chemistry wherein the improvement is the use of Lewis acids as activators for formation of the phosphorous-oxygen bond.

L'invention concerne un procédé permettant d'effectuer la synthèse d'oligonucléotides par chimie des phosphoramidites, l'amélioration consistant à utiliser des acides de Lewis comme activateurs, afin de créer la liaison phosphore-oxygène.

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