Oligonucleotide therapeutic agent and methods of making same

Details Oligonucleotide therapeutic agent and methods of making same Oligonucleotide therapeutic agent and methods of making same

C - Chemistry, Metallurgy

12

N

195/1.14, 195/1.

C12N 15/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 1208147

OLIGONUCLEOTIDE THERAPEUTIC AGENT AND METHODS OF MAKING SAME ABSTRACT For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substan- tially complementary to a portion of messenger ribo- nucleic acid coding for a biological component, such as a protein, of the organism. The oligonucleotide has about fourteen bases or more, such as twenty-three bases, and can be a deoxyribonucleotide. The oligonucleotide sequence can be derived from the organism's ribonucleic or deoxyribonucleic acid that codes for a vital protein, and can be synthesized in bulk either chemically or by insertion into a plasmid.

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