A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250923
The invention generally provides for compositions and methods of inhibiting the proliferation of human melanoma cancer cells. By administering a therapeutically effective amount of a c-myc oligonucleotide to a human melanoma cancer cell, melanoma cancer cell proliferation can be arrested or inhibited, metastases reduced from a tumor, and apoptosis induced in melanoma cancer cells. Oligonucleotides that are complementary to c-myc polynucleotides are referred to herein as "c-myc oligonucleotides". A particularly efficacious embodiment of the invention relates to compositions and methods concerning the co-administration of c-myc oligonucleotides and cisplatin.
L'invention concerne des compositions et des procédés servant à inhiber la prolifération des cellules cancéreuses de mélanomes humains. L'administration d'une quantité efficace sur le plan thérapeutique d'un oligonucléotide de c-myc à une cellule cancéreuse de mélanome permet d'inhiber ou d'arrêter la prolifération cellulaire, de limiter les métastases à partir d'une tumeur et de provoquer l'apoptose dans les cellules cancéreuses du mélanome. Les oligonucléotides complémentaires des polynucléotides de c-myc sont désignés "oligonucléotides de c-myc". Un mode de réalisation particulièrement efficace de l'invention concerne des compositions et des procédés relatifs à l'administration conjointe d'oligonucléotides de c-myc et de cisplatine.
Fetherstonhaugh & Co.
Istituto Regina Elena
LandOfFree
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