C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2652539
The invention relates to therapeutic antisense oligonucleotides directed against genes encoding phosphodiesterases (PDE) and the use of these antisense oligonucleotides in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treatment of disease associated with reduced cellular cAMP in a patient, such as inflammatory diseases of the respiratory tract including, for example, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, bronchitis, chronic bronchitis, silicosis, pulmonary fibrosis, lung allograft rejection, allergic rhinitis and chronic sinusitis as well as other conditions in which an increase in cyclic AMP or a decrease in PDE levels is beneficial.
La présente invention concerne des oligonucléotides antisens thérapeutiques dirigés contre des gènes codant pour des phosphodiestérases (PDE) et l'utilisation de ces oligonucléotides antisens combinés. Ces oligonucléotides antisens peuvent être utilisés en tant qu'outils analytiques et/ou agents thérapeutiques dans le traitement de maladies associées à un contenu cAMP cellulaire réduit chez un patient, telles que des maladies inflammatoires des voies respiratoires incluant, par exemple, l'asthme, la bronchopneumopathie chronique obstructive (BPCO), le syndrome de détresse respiratoire aiguë, la bronchite, la bronchite chronique, la silicose, la fibrose pulmonaire, le rejet d'une allogreffe pulmonaire, la rhinite allergique et la sinusite chronique, ainsi que d'autres pathologies dans lesquelles une augmentation de l'AMP cyclique ou une réduction des niveaux de PDE est bénéfique.
D'anjou Helene
Paquet Luc
Renzi Paolo
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Topigen Pharmaceuticals Inc.
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