C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C12N 15/37 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) C40B 40/06 (2006.01)
Patent
CA 2694984
An in vitro selection method is described which identifies oligonucleotide probes that discriminate amongst closely related nucleic acid sequences and which involves iterative hybridizations, including subtractive hybridization. Using the method, oligonucleotides are identified which can discriminate among human papilloma virus (HPV) subtypes. Corresponding methods and kits for the detection of nucleic acids are described, which methods and kits may be used in analytical, diagnostic, research and related applications.
La présente invention concerne un procédé de sélection in vitro qui identifie des sondes oligonucléotidiques susceptibles de distinguer des séquences d'acides nucléiques étroitement apparentées et qui implique des hybridations itératives, y compris une hybridation soustractive. Le procédé permet d'identifier des oligonucléotides qui peuvent distinguer des sous-types de virus du papillome humain (HPV). L'invention concerne en outre des procédés correspondants et des trousses correspondantes qui permettent la détection d'acides nucléiques, lesdits procédés et lesdites trousses pouvant servir à des applications analytiques, diagnostiques, de recherche et autres applications associées.
Brukner Ivan
Krajinovic Maja
Labuda Damian
Chu Sainte-Justine Le Centre Hospitalier Universitaire Mere-Enfant
Goudreau Gage Dubuc
Valorisation Hsj Limited Partnership
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