Oligonucleotides for genotyping thymidylate synthase gene

Details Oligonucleotides for genotyping thymidylate synthase gene Oligonucleotides for genotyping thymidylate synthase gene

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2500129

Oligonucleotides for genotyping the thymidylate synthase gene are provided. The number of tandem repeats in the promoter region of the thymidylate synthase gene can be identified based on the hybridization of an oligonucleotide of the invention to the genomic DNA of a subject. Therefore, the genotype of the thymidylate synthase gene can be identified based on the number of tandem repeats. The genotype relates to the responsiveness of a subject towards an antitumor agent.

La présente invention a trait à des oligonucléotides pour le génotypage du gène de thymidylate synthase. Le nombre de séquences répétées en tandem dans la région promotrice du gène de la thymidylate synthase peut être identifiée en fonction de l'hybridation d'un oligonucloétide de l'invention à l'ADN génomique d'un sujet. Ainsi, le génotype de la thymidylate synthase peut être identifié à partir du nombre de séquences de répétition en tandem. Le génotype est associé à la sensibilité d'un sujet vis-à-vis d'un agent antitumoral.

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