Oligonucleotides for modulating the effects of...

Details Oligonucleotides for modulating the effects of... Oligonucleotides for modulating the effects of...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07K 14/045 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2089666

Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising con- tacting CMV mRNA with an oligonucleotide or oligonucleotide analog which can bind with at least portions of the CMV RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind with portions of the CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. In accordance with a preferred embodiment, meth- ods of treatment of human cytomegalovirus are disclosed.

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