Oligonucleotides for treating inflammation and neoplastic...

Details Oligonucleotides for treating inflammation and neoplastic... Oligonucleotides for treating inflammation and neoplastic...

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 31/712 (2006.01) A61K 31/713 (2006.01) C12N 15/11 (2006.01) C07H 21/00 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2724179

There is provided oligonucleotides directed against the CCR3 receptor and the common beta sub-unit of IL-3, IL-5 and GM-CSF receptors. The oligonucleotides are useful to inhibit general inflammation, including inflammation associated with asthma, COPD, allergy, Cystic fibrosis (CF), hypereosinophilia and neoplastic cell proliferation such as cancer.

Linvention concerne des oligonucléotides dirigés contre le récepteur CCR3 et la sous-unité bêta commune des récepteurs IL-3, IL-5 et GM-CSF. Les oligonucléotides sont utiles pour inhiber linflammation générale, y compris linflammation associée avec lasthme, la BPCO, les allergies, la fibrose cystique (CF), lhyperéosinophilie et la prolifération des cellules néoplasiques telle que le cancer.

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