Oligonucleotides or their functional homologues, a...

Details Oligonucleotides or their functional homologues, a... Oligonucleotides or their functional homologues, a...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/7088 (2006.01) C12N 15/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2609062

The invention provides nine oligonuleotides with sequences of SEQ ID NO: 1-9 or their functional homologues or a composition comprising the same and a method for treating B cell neoplasm by using the oligonuleotides or their functional homologues or the composition comprising the oligonuleotides. The oligonuleotides induce the apoptosis of B cell neoplastic cells, up-regulate CD40 on B cell neoplastic cells and stimulate the production of IL-10 from B cell neoplastic cells.

L~invention concerne neuf oligonucléotides avec des séquences de SEQ ID NO: 1 à 9 ou leurs homologues fonctionnels ou une composition les comprenant et un procédé pour le traitement des tumeurs à lymphocytes B en utilisant les oligonucléotides ou leurs homologues fonctionnels ou les compositions comprenant les oligonucléotides. Les oligonucléotides induisent l~apoptose des cellules néoplasiques à lymphocytes B, régulent par le haut le CD40 sur les cellules néoplasiques à lymphocytes B et stimulent la production de l~IL-10 à partir des cellules néoplasiques à lymphocytes B.

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