C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2222520
The present invention relates to oligonucleotides which are effective inhibitors of disease-associated cellular proliferation and methods of their use. In particular, it relates to the use of oligonucleotides which are substantially complementary to gp130 mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
L'invention porte sur des oligonucléotides s'avérant être d'efficaces inhibiteurs de la prolifération cellulaire liée à certaines maladies et sur leur mode d'utilisation. Elle porte plus particulièrement sur l'utilisation d'oligonucléotides sensiblement complémentaires des séquences d'ARNm de gp130. Sous la forme de préparations pharmaceutiques, ces oligonucléotides peuvent être administrés à l'homme pour traiter la prolifération cellulaire anormale liée à certaines maladies telles que le cancer, les maladies auto-immunes et les infections virales.
Becherer Kathleen Ann
Dattagupta Nanibhushan
Naidu Yathi M.
Gen-Probe Incorporated
Smart & Biggar
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