Oligonucleotides targeting prion diseases

Details Oligonucleotides targeting prion diseases Oligonucleotides targeting prion diseases

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2538245

Randomer phosphorothioate oligonucleotide compositions have been described that inhibit PrPc conversion to PrPcs with a high level of potency. Pharmaceutical compositions or kits containing such compounds, and methods of using such compounds in the treatment, control, or prevention of prion diseases are also described.

L'invention concerne des composés agissant contre les maladies à prions, des compositions pharmaceutiques et des trousses contenant de tels composés, et des procédés d'utilisation de ces composés dans le traitement, la régulation ou la prévention de maladies à prions.

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