Oligonucleotides with anti-mdr-1 gene activity

Details Oligonucleotides with anti-mdr-1 gene activity Oligonucleotides with anti-mdr-1 gene activity

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2195397

Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to at least a portion of the multi-drug resistant-1 gene, or transcripts thereof, which portion encodes a nucleoside binding site. Also disclosed is a pharmaceutical formulation containing such oligonucleotides, and methods of treating multidrug resistant cancer cells, of preventing the expression of P170 in a cell, and of preventing the induction of multidrug resistance in a cancer cell.

L'invention concerne un oligonucléotide synthétique comprenant une séquence nucléotidique complémentaire d'au moins une partie du gène 1 résistant à des médicaments multiples, ou des produits de transcription de ce dernier, ladite partie codant un site de liaison nucléosidique. Elle porte également sur une formule pharmaceutique contenant lesdits oligonucléotides et sur des méthodes de traitement des cellules cancéreuses résistant à de multiples médicaments, de prévention de l'expression de P170 dans une cellule, et de prévention de l'induction de la résistance à des médicaments multiples dans une cellule cancéreuse.

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