Oligonucleotides with anti-respiratory syncytial virus activity

Details Oligonucleotides with anti-respiratory syncytial virus activity Oligonucleotides with anti-respiratory syncytial virus activity

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2181546

Disclosed are oligonucleotides which hybridize to a portion of respiratory syncytial virus (RSV) genomic RNA under physiological conditions, and, in doing so, inhibit viral replication. Also disclosed are pharmaceutical compositions and methods useful for inhibiting and treating RSV infection and including at least one or two of these oligonucleotides, or at least one of these oligonucleotides and ribavirin.

L'invention se rapporte à des oligonucléotides qui s'hybrident sur une partie de l'ARN génomique du virus respiratoire syncitial (VRS) selon des états physiologiques, et se faisant, inhibent la réplication virale. L'invention se rapporte également à des compositions pharmaceutiques et à des procédés utilisés pour inhiber et traiter les infections dues au VRS, ces compositions renfermant au moins un ou deux de ces oligonucléotides ou au moins un de ces oligonucléotides et la ribavirine.

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