Oligopeptide anticancer and antiviral agents

Details Oligopeptide anticancer and antiviral agents Oligopeptide anticancer and antiviral agents

C - Chemistry, Metallurgy

07

K

260/300, 260/363

C07K 7/06 (2006.01) C07D 207/34 (2006.01) C07K 5/04 (2006.01) A61K 37/02 (1990.01)

Patent

CA 1308516

ABSTRACT OF THE DISCLOSURE Oligopeptide anticancer and antiviral agents are represented by the formula: A-(NHCO)m-Het-(NHCO-Het)n-NH-R-NH-(Het-CONH)n-Het (CONH)m-A wherein A is a moiety bearing a positive charge and of a size which avoids steric inhibition of binding of said compound to deoxyribonucleic acid sequence; R is a moiety derived from a dicarboxylic acid; Het is a five-membered heterocyclic moiety; n is 1, 2 or 3, m is 0 or 1. These compounds exhibit antiviral activity especially against herpes simplex I and II, vaccinia viruses and anticancer activity against several animal and human tumor lines.

541352

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