Oligopeptide antiretroviral agents

Details Oligopeptide antiretroviral agents Oligopeptide antiretroviral agents

C - Chemistry, Metallurgy

07

K

C07K 5/027 (2006.01) A61K 31/33 (2006.01) A61K 38/06 (2006.01) C07D 207/34 (2006.01) C07D 231/40 (2006.01) C07D 233/90 (2006.01) C07D 249/02 (2006.01) C07D 263/48 (2006.01) C07D 277/56 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2103665

Oligopeptide antiretroviral agents are represented by the formula: Image wherein A is a moiety bearing a positive charge and of a size which avoids steric inhibition of binding of said compound to nucleic acid sequences associated with the cellular activity of retroviruses; R1 is a moiety derived from a dicarboxylic acid; Het is a five-membered heterocyclic moiety; y and z are independently 0, 1, 2 or 3; and x is 0 or 1. These compounds exhibit antiretroviral activity, especially against Human Immunodeficiency Virus (HIV).

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