C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/083 (2006.01) C07K 1/06 (2006.01) C07K 5/087 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C12Q 1/56 (2006.01) G01N 27/26 (2006.01) G01N 27/416 (2006.01) G01N 27/48 (2006.01) G01N 33/483 (2006.01) G01N 33/49 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2363827
The invention relates to oligopeptide derivatives whose C-terminal amino acid is arginine which is linked to the remainder of an electroactive aniline or aminoquinoline derivative by an amide bond. Said oligopeptide derivatives are split by enzymes of the class of peptide hydrolases, especially proteinases and their inhibitors, of the coagulation system, the fibrinolytic system and the complement, especially of thrombin. These oligopeptide derivatives therefore serve as a substrates for quantitatively determining such enzymes, especially thrombin, in complex sample liquids, especially capillary blood. This determination is carried out by measuring the increase in the water- soluble amperogenic aniline or aminoquinoline compound. The oligopeptide derivative and their salts can be produced according to usual methods in peptide chemistry.
Dérivés d'oligopeptides dont l'acide aminé C-terminal est arginine attachée par une liaison amide avec le reste d'un dérivé électroactif d'aniline ou d'aminochinoline. Lesdits dérivés sont clivés par des enzymes de la classe des hydrolases peptidiques, en particulier des protéinases et leurs inhibiteurs, du système de coagulation du sang, du système fibrinolytique et du complément, en particulier de la thrombine. Ces dérivés d'oligopeptides servent de substrats pour la détermination quantitative desdites enzymes, en particulier la thrombine, dans des échantillons liquides complexes, en particulier du sang capillaire. Lors d'une telle détermination est mesurée l'augmentation du composé aniline ou aminochinoline ampérogène hydrosoluble. Lesdits dérivés d'oligopeptides et leurs sels peuvent être préparés selon des procédés courants dans la chimie des peptides.
Ludin Christian
Schulze Andreas
Svendsen Lars G.
Wikstroem Peter
Blake Cassels & Graydon Llp
Pentapharm Ag
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