Oligopeptides and intermediates and processes for their...

Details Oligopeptides and intermediates and processes for their... Oligopeptides and intermediates and processes for their...

C - Chemistry, Metallurgy

12

N

195/1.235, 195/1

C12N 15/16 (2006.01) A61K 38/23 (2006.01) C07K 14/585 (2006.01)

Patent

CA 1339365

Described are peptides that have, as partial sequence of a larger peptide, or exclusively, the amino acid sequence of the formula I -AlaCysAsnThrAlaThrCysValThrHisArgLeuAlaGlyLeuLeuSer- ArgSerGlyGlyMetValLysSerAsnPheValProThrAsnValGlySer- (I) LysAlaPhe- in which the cysteine residues can form intra- or inter-molecular disulphide bridges, and derivatives thereof having an amidated terminal carboxy group and/or an acylated terminal amino group, and their salts, DNA sequences that code for the mentioned peptides, micro-organisms that contain these DNA sequences, processes for the manufacture thereof, pharmaceutical preparations that contain the mentioned peptides in the form of their amides, and the use of these peptide-amides for the treatment of coronary circulation disorders and bone metabolism disorders.

499545

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