Oligopeptides for reducing elevated blood urea concentration

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2561833

The invention includes a method of reducing urea concentration in a subject's serum. Such a method comprises administering to the subject (e.g., a mammal such as a human) a composition comprising an oligopeptide (or oligopeptides) having activity in reducing urea concentration in the subject's serum as determined by a mouse renal reperfusion test, wherein the oligopeptide comprises the sequence QGV or MTRV (SEQ ID NO:1) (e.g., AQGV (SEQ ID NO:2) or MTRV (SEQ ID NO:1)).

L'invention concerne une méthode permettant de réduire une concentration d'urée dans le sérum d'un sujet. Ladite méthode consiste à administrer à ce sujet (par exemple, un mammifère tel qu'un humain) une composition comprenant un oligopeptide (ou des oligopeptides) actif dans la réduction de la concentration d'urée dans le sérum d'un sujet telle que déterminée au moyen d'un essai de reperfusion rénale de souris, ledit oligopeptide comprenant la séquence QGV ou MTRV (SEQ ID NO:1) (par exemple, AQGV (SEQ ID NO:2) ou MTRV (SEQ ID NO:1)).

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