Oligopeptides with cyclic proline-analogous amino acids

Details Oligopeptides with cyclic proline-analogous amino acids Oligopeptides with cyclic proline-analogous amino acids

C - Chemistry, Metallurgy

07

K

167/215, 167/103

C07K 5/04 (2006.01) A61K 31/535 (2006.01) C07K 1/10 (2006.01) C07K 5/065 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1331498

-1- Abstract of the disclosure Oligopeptides with cyclic proline-analogous amino acids The invention relates to compounds of the formula I (I) Image in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl compound; D represents NH, NCH3, O or CH2; E represents CHOH, CO, SO or optionally N- substituted C=NH; F represents O, NH, NCH3 or a bond; R4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R8 denotes hydrogen or optionally substituted alkyl, to a process for the preparation thereof, and to the use thereof as inhibitors of prolyl hydroxylase.

601590

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