Oligopeptidyl nitrile derivatives, agents containing them, a...

Details Oligopeptidyl nitrile derivatives, agents containing them, a... Oligopeptidyl nitrile derivatives, agents containing them, a...

C - Chemistry, Metallurgy

07

K

530/5.04

C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/08 (2006.01) C07K 5/087 (2006.01)

Patent

CA 1312702

- 1 - BEHRINGWERKE AKTIENGESELLSCHAFT 86/B 007 - Ma 561 Dr. Ha/Bn Abstract of the Disclosure Compounds of the formula I A-R-NH-CHR1-(CH2)a-NHC(=NH)NH2 in which R1 is the cyanide group, R is Pro or D-Phe-Pro, A is a hydrogen atom or a protective group customary in peptide chemistry, and a is an integer from 2 to 5, preferably 3 or 4, which are able to inhibit serine proteases, and a process for their preparation, are described. Agents containing compounds of this type can be used as anticoagulants.

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