A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2580126
The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
L'invention porte sur un composé à double brin, de préférence un oligoribonucléotide, qui freine l'expression d'un gène humain p53. Cette invention porte aussi sur une composition pharmaceutique contenant ce composé, ou un vecteur capable d'exprimer le composé d'oligoribonucléotide, ainsi qu'un support pharmaceutiquement acceptable. L'invention se rapporte également à un procédé de traitement d'un patient souffrant d'alopécie ou d'insuffisance rénale aiguë ou d'autres maladies, consistant à administrer au patient la composition pharmaceutique dans une dose thérapeutiquement efficace afin de traiter le patient. L'alopécie peut être causée par la chimiothérapie ou la radiothérapie, et la patient peut souffrir d'un cancer, notamment un cancer du sein.
Ehrlich Shai
Feinstein Elena
Zurr Daniel
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Quark Biotech Inc.
Quark Pharmaceuticals Inc.
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