Oligoribonucleotides with amide backbone

Details Oligoribonucleotides with amide backbone Oligoribonucleotides with amide backbone

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2163392

Oligomers having amide linkages of the following formula: Image wherein R1 is H, C1-4 alkyl, C1-18-acyl or hydroxy-lower alkyl; R2 is H, aralkyl, or C1-4 alkyl; B is a nucleoside base residue selected from the group consisting of adenine, cytosine, guanine, thymine, uracil; X is H, OR1, NHR2 or NH-acyl; Y is OR2 or NHR2; and n is a number from 5 through 25, and salts thereof.

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