Oligosaccharide synthesis

Details Oligosaccharide synthesis Oligosaccharide synthesis

C - Chemistry, Metallurgy

07

C

C07C 59/353 (2006.01) C07C 59/90 (2006.01) C07C 69/716 (2006.01) C07C 69/738 (2006.01) C07C 229/32 (2006.01) C07C 257/06 (2006.01) C07H 5/06 (2006.01) C07H 15/18 (2006.01) C08J 7/14 (2006.01) C08J 7/16 (2006.01)

Patent

CA 2264390

The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O- glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.

L'inventon concerne un système de synthèse en phase solide d'oligosaccharides, consécutif à la découverte du fait qu'un groupe lieur 1,3-dioxycycloalkyl 2-substitué de la formule générale (I) peut être utilisé pour coupler des groupes saccharide des types O-glycoside et N-glycoside à un support polymère. L'invention concerne des réactifs, des trousses de réactifs et des procédés de synthèse en phase solide d'oligosaccharides.

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