Oligosaccharides comprising an aminooxy group and conjugates...

Details Oligosaccharides comprising an aminooxy group and conjugates... Oligosaccharides comprising an aminooxy group and conjugates...

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61K 31/738 (2006.01) A61K 47/48 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2675968

The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.

L'invention concerne des procédés pour la synthèse d'oligosaccharides comprenant un groupe aminooxy. L'invention concerne en outre des oligosaccharides comprenant un groupe aminooxy, les procédés pour le couplage d'oligosaccharides comprenant un groupe aminooxy à des glycoprotéines et des conjugués d'oligosaccharide-protéine. Sont également proposés des procédés de traitement d'un trouble de stockage lysosomal chez un mammifère par l'administration d'un conjugué d'oligosaccharide-protéine.

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