C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/04 (2006.01) A61K 39/102 (2006.01) C07H 15/18 (2006.01) C07H 15/20 (2006.01)
Patent
CA 2382602
The present invention relates to the field of medicine, in particular to the chemical synthesis of mixtures of oligosaccharides derived from ribose-ribitol-phosphate which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as to vaccines which comprise said mixture of oligosaccharides. The mixtures of oligosaccharides which have been obtained by chemical synthesis comprise repetitive units having the formula (phosphate-ri-bose-ribitol)n or (ribose-ribitol-phosphate)n of at least five compounds having structure A or B which represent the repetitive unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, n being higher than or equal to 4 and smaller than or equal to 25, and wherein R1 or R2 is a spacer for the conjugation to a carrier with the condition that R1 = spacer if R2 the = H, or R2 = spacer if R1 = H: (A), (B). The invention also relates to immunogens which contain said oligosaccharide mixtures, to vaccines which contain said immunogens and to methods for preparing said oligosaccharides in the form of mixtures. Furthermore, the invention relates to the use of the vaccines either separately or combined to other vaccines for the prevention of infections caused by Haemophilus influenzae type b.
L'invention concerne le domaine de la médecine, et notamment la synthèse chimique de mélanges d'oligosaccharides dérivés de ribose-ribitol-phosphate, lesquels sont utilisés comme principe actif dans des vaccins destinés à la prévention d'infections dues à <i>Haemophilus influenzae</i> du type b (Hib). L'invention concerne également les vaccins qui contiennent ces mélanges d'oligosaccharides. Ces mélanges d'oligosaccharides obtenus par synthèse chimique, contiennent des unités répétitives représentées par la formule (phosphate-ribose-ribitol)n ou (ribose-ribitol-phosphate)n ayant au moins 5 composés de structure A ou B, lesquels représentent l'unité répétitive du polysaccharide capsulaire de <i>Haemophilus influenzae</i> du type b (Hib) et ne diffèrent que par n, n étant = 4 et = 25, et où R1 ou R2 est un séparateur destiné à la conjugaison d'un support, à la condition que R1 soit un séparateur si R2 est un séparateur si R1 est égal à H: (A), (B). L'invention concerne également les immunogènes qui contiennent ces mélanges d'oligosaccharides, les vaccins qui contiennent ces immunogènes ainsi que les méthodes de préparation de ces oligosaccharides sous forme de mélanges. L'invention concerne enfin l'utilisation des vaccins seuls ou combinés avec d'autres vaccins afin de prévenir les infections dues à <i>Haemophilus influenzae</i> du type b.
Roy Rene
Verez Bencomo Vicente Guillermo
Macrae & Co.
Universidad de La Habana
University Of Ottawa
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