Oligosaccharides having growth factor binding affinity

Details Oligosaccharides having growth factor binding affinity Oligosaccharides having growth factor binding affinity

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) C07H 3/06 (2006.01) C08B 37/00 (2006.01) A61K 31/725 (1990.01)

Patent

CA 2132750

2132750 9319096 PCTABS00025 Oligosaccharides having a high specific binding affinity for FGF growth factors and made up of less than ten disaccharide units in all are disclosed which include sulphated disaccharide units composed of an N-sulphated glucosamine residue and a 2-0-sulphated iduronic acid residue. A method is also disclosed for preparing these oligosaccharides in a purified and relatively homogeneous state from glycosaminoglycans such as heparan sulphate. For the best FGF-binding affinity there are preferably at least four of the sulphated disaccharide units arranged as an internal contiguous sequence. The most favoured structures contain fourteen monosaccharide residues in all, but structures having twelve monosaccharide residues can also have quite high FGF-binding affinity, at least for bFGF. These oligosaccharides can either activate and stimulate FGF activity or inhibit FGF activity, and uses thereof as drugs for therapeutic purposes in medicine are also disclosed.

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