.omega.-[2-(n-lower alkyl-benzamido)-phenyl]-alkanoic acids,...

Details .omega.-[2-(n-lower alkyl-benzamido)-phenyl]-alkanoic acids,... .omega.-[2-(n-lower alkyl-benzamido)-phenyl]-alkanoic acids,...

C - Chemistry, Metallurgy

07

D

260/515.5

C07D 223/16 (2006.01) C07D 215/227 (2006.01)

Patent

CA 1133936

ABSTRACT .omega.-[2-(N-lower alkyl-benzamido)-phenyl]-alkanoic acids of the general formula I Image (I), wherein n denotes a positive whole number from 2 to 5, R1 denotes a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylmercapto group, a trifluoromethyl group or a phenyl group which may be substituted by a halogen atom or a lower alkoxy group, R2 denotes a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, R3 denotes a lower alkyl group, R4 denotes a hydrogen atom, a halogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group, a lower alkylmercapto group, a phenyl group which may be substituted by a halogen atom or a nitro group, a nitro group, an amino group which may be lower alkylated, a lower alkylcarbonyl group, a benzoyl group which may be sub- stituted by a halogen atom, a trifluoromethyl group, a trifluoromethoxy group or a trifluoromethylmercapto group, R5 denotes a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, R6 denotes a hydrogen atom, a lower alkyl group or a lower alkoxy group, and their salts with inorganic or organic bases, are new compounds. They have a hypoglycaemic effect and inhibit the glucose formation in the liver. Processes for their preparation are stated.

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