.omega.-(n-acylamino) alkylphosphoryl ethanolamines, process...

Details .omega.-(n-acylamino) alkylphosphoryl ethanolamines, process... .omega.-(n-acylamino) alkylphosphoryl ethanolamines, process...

C - Chemistry, Metallurgy

07

F

260/460.5

C07F 9/09 (2006.01)

Patent

CA 1052810

ABSTRACT OF THE DISCLOSURE New .omega.-(N-acylamino)alkylphosphoryl ethanolamines and their pharmaceutically acceptable acid addition salts having superior renin-inhibitory activities, antihypertensive activities alkylphosphoryl ethanolamines are prepared by (1) reacting an .omega.-(N-acylamino) alkanol with a 2-(N-substituted amino)ethyl phosphate or its derivative, hydrolyzing the resulting product or splitting off the phosphoric acid-protective group of the result- ing product thereby to form an .omega.-(N-acylamino) alkyl-2-(N-substi- tuted amino) ethyl phosphate, and splitting off the amino- protective groups of the resulting phosphate, or (2) reacting an .omega.-(N-acylamino) alkanol with a phosphorus oxyhalide, reacting the resulting .omega.-(N-acylamino)alkyl dichlorophosphate with a 2-(N-substituted amino) ethanol, hydrolyzing the reaction product to from an .omega.-(N-acylamino)alkyl 2-(N-substituted)ethyl phosphate, and splitting off the amino-protective groups of said phosphate. - 1 -

217746

Affiliated with

Also associated with

Rating

.omega.-(n-acylamino) alkylphosphoryl ethanolamines, process... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .omega.-(n-acylamino) alkylphosphoryl ethanolamines, process..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .omega.-(n-acylamino) alkylphosphoryl ethanolamines, process... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-612023