.omega.-nor-cycloalkyl-13,14-dehydro-prostaglandins and...

Details .omega.-nor-cycloalkyl-13,14-dehydro-prostaglandins and... .omega.-nor-cycloalkyl-13,14-dehydro-prostaglandins and...

C - Chemistry, Metallurgy

07

D

260/235.03

C07D 317/34 (2006.01) C07C 405/00 (2006.01) C07D 307/935 (2006.01) C07D 309/12 (2006.01) C07F 9/40 (2006.01) C07F 9/54 (2006.01) C07F 9/564 (2006.01) C07F 9/58 (2006.01)

Patent

CA 1083569

A B S T R A C T New therapeutically useful optically active or racemic pros- taglandins of the following general formula (I) (I) Image wherein R is a hydrogen atom, a C1-C12 alkyl group or a cation of a pharma- ceutically acceptable base; the symbol Image represents a single or a double bond, wherein, when the symbol Image is a double bond, R1 is a hydrogen atom, and R2 and R3 together form an oxo group, while, when the symbol Image is a single bond, R1 is hydroxy, R2 is hydrogen and R3 is hydroxy or a carboxy- lic acyloxy or R2 and R3, taken together, form an oxo group; one of R4 and R5 is hydroxy and the other is hydrogen; R6 and R7 are independently hydro- gen or C1-C4 alkyl; n is zero, 1, 2 or 3; R8 is a radical Image , wherein m is 1, 2, 3, 4 or 5 and W is -CH2-, an oxygen atom, a sulphur atom or a radical Image , wherein R9 is hydrogen or C1-C4 alkyl, or R8 is 1-adamantyl, 2-nor-bornyl, 2-bicyclo [2,2,2]-octyl or 4-t.butyl- cyclohexyl,

234796

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