Omeprazole sodium salt

Details Omeprazole sodium salt Omeprazole sodium salt

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2294614

This invention relates to a novel form of the sodium salt of 5-methoxy-2-[ [(4- methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]-1<u>H</u>-benzimidazole, known under the generic name of omeprazole sodium salt. This invention also relates to processes for its preparation of omeprazole sodium form B which is thermodynamically stable, as well as pharmaceutical compositions containing it and its use in the treatment of gastrointestinal disorders.

L'invention concerne une nouvelle forme de sel de sodium de 5-méthoxy-2-[ [(4-méthoxy-3,5-diméthyl-2-pyridinyl) méthyl]sulfinyl]-1H-benzimidazole, connu sous le nom générique de sel de sodium d'oméprazole. L'invention concerne également des procédés de préparation du sodium d'oméprazole de forme B qui est thermodynamiquement stable, ainsi que des compositions pharmaceutiques le contenant et son utilisation dans le traitement de troubles gastro-intestinaux.

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