On-line synthesis with an immobilized enzyme cascade

Details On-line synthesis with an immobilized enzyme cascade On-line synthesis with an immobilized enzyme cascade

C - Chemistry, Metallurgy

12

M

C12M 1/40 (2006.01) C12M 1/36 (2006.01) C12N 11/14 (2006.01) C12N 11/18 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2309510

The present invention relates to the use of multiple immobilized enzyme reactors (IMERs) in a liquid chromatographic system to perform enzymatic transformations and compound synthesis. The system is characterized by the utilization of separate IMERs and therefore constitutes a modular approach to multiple on-line synthesis. Individual IMERs can be added, subtracted or replaced to meet the requirements of a chosen synthetic plan. The system can be used for designed synthetic pathways or to mimic natural biosynthetic processes. Alternatively, the system as a whole, or each IMER separately, can be used for the discovery and characterization of new drug candidates. The present invention is exemplified by the synthesis of individual IMERs in the biosynthetic pathway that converts tyrosine to epinephrine.

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