A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/198 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2721722
The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog resistant tumors have developed, including identify- ing a subject having cancer susceptible to treatment with a nucleotide analog chemotherapeutic agent and a mitotic disruptor/ polo-like kinase (Plk) pathway inhibitor to a subject; and monitoring the subject for a reduction or stabilization of at least one sign or symptom of cancer.
L'invention porte sur des compositions et des procédés de traitement de cancers sensibles à un traitement par un agent chimiothérapeutique d'analogue nucléotidique, comprenant des cancers dans lesquels des tumeurs résistantes à un analogue nucléotidique se sont développées, comprenant l'identification d'un sujet atteint d'un cancer sensible à un traitement par un agent chimiothérapeutique d'analogue nucléotidique et un inhibiteur de la voie de disrupteur mitotique/kinase de type polo (Plk) à un sujet; et la surveillance du sujet pour une réduction ou une stabilisation d'au moins un signe ou symptôme du cancer.
Hidalgo Manuel Medina
Jimeno Antonio
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Johns Hopkins University
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