Once-a-day metoprolol oral dosage form

A - Human Necessities – 61 – K

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Details

A61K 31/135 (2006.01) A61K 9/20 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2164619

A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic cross-linking agent. The formulation provides release of metoprolol for at least about 24 hours. Methods of preparation and methods of treatment using the preparations of the invention are also disclosed.

Une forme galénique solide, à administration par voie orale et à libération prolongée, de la formulation pharmaceutique métoprolole, comprend un excipient à libération prolongée renfermant un agent gélifiant, un diluant pharmaceutique inerte, un agent de réticulation cationique. La formulation assure une libération du métoprolole pendant au moins 24 heures. Des procédés de préparation et des procédés de traitement utilisant ces préparations sont également décrits.

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