Once-a-day, oral, controlled-release, oxycodone dosage forms

Details Once-a-day, oral, controlled-release, oxycodone dosage forms Once-a-day, oral, controlled-release, oxycodone dosage forms

A - Human Necessities

61

K

A61K 31/485 (2006.01)

Patent

CA 2546691

Oxycodone formulations are provided which produce substantially flat in vivo steady state plasma profiles. Tolerance levels associated with such profiles and tolerance levels associated with biphasic profiles are shown not to be statistically different. The substantially flat in vivo steady state plasma profiles are produced by dosage forms having substantially zero order in vitro release profiles. Such release profiles produce low single dose in vivo Cmax levels which can reduce the probability of adverse side effects.

L'invention porte sur des préparations d'oxycodone produisantin vivo des profils plasmatiques sensiblement constants. Les niveaux de tolérance associés à ces profils et ceux associés aux profils biphasés se sont avérés statistiquement identiques. Ces profils plasmatiques sensiblement constants in vivo sont produits par des formes posologiques présentant des profils <i> in vitro</i> d'ordre sensiblement nul. De tels profils de libération produisent <i>in vivo</i> pour une faible dose unique des niveaux de C¿max? pouvant réduire la probabilité d'effets secondaires adverses.

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