Onco-tool compositions and methods of use for detecting and...

A - Human Necessities – 61 – K

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A61K 31/16 (2006.01) A61K 31/185 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2647502

One of the most universal characteristics of malignant tumors is their acidity. Onco-tools are small non-peptide synthetic molecules designed to exploit this acidity for early detection and destruction of tumors. Each onco-tool has a structure which is anionic and hydrophilic at pH 7.4 and so repels from the negatively-charged surfaces of cells in normal tissues. When an onco-tool enters an acidic environment, such as in a tumor, a portion of the onco-tool molecules switch to their non-ionic lipophilic form which is designed to enter cells, such as cells in acidic areas of tumors. Prior to use of an onco-tool, a selected radioisotope is linked to the onco-tool. If that radioisotope emits radiation which can be detected outside the body, then the onco-tool can serve for detecting tumors. If that radioisotope emits radiation effective to kill cells, then the onco-tool can serve for treating tumors.

L'une des caractéristiques les plus universelles des tumeurs malignes est leur acidité. Les outils oncologiques sont de petites molécules synthétiques non peptides conçues pour exploiter cette acidité pour une détection et destruction précoce des tumeurs. Chaque outil oncologique présente une structure qui est anionique et hydrophile au pH 7.4 et crée une répulsion par rapport aux surfaces à charges négatives des cellules de tissus normaux. Quand un outil oncologique pénètre dans un environnement acide tel qu'une tumeur, une partie des molécules outils oncologiques passent à leur forme lipophile non ionique qui est conçue pour pénétrer les cellules, notamment les cellules des zones acides des tumeurs. Avant d'utiliser un outil oncologique, on lui relie un radioisotope sélectionné. Si ce radioisotope émet un rayonnement détectable à l'extérieur du corps, l'outil oncologique convient à la détection de tumeurs. Si ce radioisotope émet un rayonnement capable de tuer des cellules, l'outil oncologique convient au traitement de tumeurs.

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