Oncolytic adenoviruses for the treatment of cancer

Details Oncolytic adenoviruses for the treatment of cancer Oncolytic adenoviruses for the treatment of cancer

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61P 35/00 (2006.01) C12N 7/00 (2006.01) C12N 15/861 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2640528

The invention relates to an oncolytic adenovirus for the treatment of cancer, containing a human DNA sequence isolating a promoter conferring selective expression on an adenoviral gene. Said adenovirus can also contain a sequence that optimises the protein translation of an adenoviral gene regulated by a promoter conferring tumour selectivity. The invention is suitable for use in the treatment of cancer.

La présente invention concerne un adénovirus oncolytique destiné au traitement du cancer, contenant une séquence d'ADN humain isolant un promoteur qui confère une expression sélective à un gène adénoviral. Cet adénovirus peut également contenir une séquence qui optimise la traduction protéique d'un gène adénoviral régulé par un promoteur qui confère une sélectivité tumorale. L'invention trouve une application dans le traitement du cancer.

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