Oncolytic virus replicating selectively in tumor cells

Details Oncolytic virus replicating selectively in tumor cells Oncolytic virus replicating selectively in tumor cells

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/075 (2006.01) C12N 7/01 (2006.01) C12N 9/12 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2491907

By using a telomerase promoter with a virus having a gene sequence containing an E1 gene (preferably E1A gene), an IRES sequence and a sequence containing E1B gene and an anticancer agent with the use of this virus, the virus grows in tumor cells and thus exhibits an efficient anticancer effect.

L'invention concerne l'utilisation d'un promoteur de la télomérase et d'un virus comprenant une séquence génique contenant un gène E1 (de préférence un gène E1A), une séquence IRES et une séquence contenant un gène E1B et un agent anticancéreux, pour faire croître le virus dans des cellules tumorales et obtenir ainsi un effet anticancéreux sensible.

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