C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/37,
C12N 15/62 (2006.01) A61K 38/19 (2006.01) C07K 14/07 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/19 (2006.01) C12N 15/53 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1338011
Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their prepar- ation and methods for their use are provided. The com- positions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions rind use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation or normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition com- positior 3 may additionally include an adjunctive agent comprising at least one or a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use or antibodies to the compo- sitions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
565721
Brown Thomas J.
Hanson Marcia B.
Linsley Peter S.
Malik Najma
Marquardt Hans
Gowling Lafleur Henderson Llp
Oncogen
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