C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/00 (2006.01) B01J 19/00 (2006.01) C07B 61/00 (2006.01) C07K 1/04 (2006.01) C12N 11/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 21/64 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/544 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) G06F 17/14 (2006.01)
Patent
CA 2321111
A method for the solid-phase synthesis of combinatorial libraries on a one- dimensional support, such as a thread, is provided. The method involves the cyclic permutation of structural features along the thread, in such a way that different structural features are repeated at a characteristic fixed frequencies along the thread. The thread is processed so as to generate a signal proportional to the activity of the compounds in the library, and the thread is then assayed by being drawn through an appropriate detector. The resulting time-domain signal is processed by Fourier transformation. Spikes in the frequency domain of the processed signal indicate the frequency at which structural features that contribute to the activity were created on the thread.
La présente invention porte sur un procédé de synthèse en phase solide de banques combinatoires effectué sur un support unidimensionnel tel qu'un fil. Le procédé implique la permutation cyclique de détails structurels le long du fil, de telle sorte que les différents détails structurels se répètent à des fréquences données caractéristiques le long du fil. Le fil est traité de manière à générer un signal proportionnel à l'activité des composés de la banque, et le fil est ensuite analysé par étirement dans un détecteur approprié. Le signal à domaine temporel résultant est traité par transformation de Fourier. Des pics dans le domaine fréquentiel du signal traité indiquent la fréquence à laquelle ont été créés sur le fil les détails structurels contribuant à l'activité.
Robic
Schwabacher Alan W.
Wisys Technology Foundation Inc.
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