One-pot processes for preparing prednisolone derivatives

Details One-pot processes for preparing prednisolone derivatives One-pot processes for preparing prednisolone derivatives

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) C07J 5/00 (2006.01) C07J 75/00 (2006.01)

Patent

CA 2568510

Disclosed is a one-pot process for the preparation of a prednisolone derivative of formula I, comprising reacting the compound of formula II with the compound of formula III and the compound of formula IV The process does not need to separate and purify the intermediate formed, and therefore the process reduces the reaction time and increases the yield of the product compared to the prior art (see formula II) (see formula III) (see formula IV) (see formula I).

Divulgation d'un processus en enceinte unique permettant de préparer un dérivé de prednisolone de la formule I et qui consiste à faire réagir le composé de la formule II avec le composé de la formule III et le composé de la formule IV. Le processus ne nécessite pas la séparation et la purification du composé intermédiaire formé, ce qui permet de réduire le temps de réaction et d'augmenter le rendement du produit par rapport à l'état antérieur de la technique (voir formule II) (voir formule III) (voir formule IV) (voir la formule I).

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