One pot synthesis of citalopram from 5-cyanophthalide

Details One pot synthesis of citalopram from 5-cyanophthalide One pot synthesis of citalopram from 5-cyanophthalide

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01)

Patent

CA 2559703

A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5- cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.

Cette invention concerne une méthode de synthèse <= one-pot >= du citalopram. Cette méthode consiste à soumettre un 5-cyano phthalide à une réduction de Grignard suivie d'une cyclisation, puis d'une réaction de C-alkylation pour obtenir du citalopram sans isolement ni purification d'intermédiaires. Dans un autre mode de réalisation, on soumet un 5-cyano phthalide à des réactions séquentielles de Grignard suivies d'un cyclisation pour obtenir du citalopram sans isolement ni purification de stades intermédiaires.

Affiliated with

Also associated with

Rating

One pot synthesis of citalopram from 5-cyanophthalide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with One pot synthesis of citalopram from 5-cyanophthalide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and One pot synthesis of citalopram from 5-cyanophthalide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1774173