One pot synthesis of taxane derivatives and their conversion...

Details One pot synthesis of taxane derivatives and their conversion... One pot synthesis of taxane derivatives and their conversion...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01)

Patent

CA 2576231

A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7, 10 and attaching a side chain at C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and intermediates used therein.

Cette invention concerne un procédé permettant d'effectuer la demi-synthèse d'intermédiaires de taxane utilisés dans la préparation de paclitaxel et de docétaxel, en particulier la demi-synthèse d'intermédiaires de taxane protégés dans une réaction monotope consistant à protéger un groupe hydroxy en position C-7 et/ou C-10 d'un taxane et à fixer une chaîne latérale en position C-13 puis à déprotéger le groupe pour former du paclitaxel ou du docétaxel. Cette invention concerne également les intermédiaires utilisés dans ce procédé.

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