Onset of antiestrogen resistance in breast cancer

Details Onset of antiestrogen resistance in breast cancer Onset of antiestrogen resistance in breast cancer

G - Physics

01

N

G01N 33/483 (2006.01) G01N 33/574 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2089162

2089162 9203973 PCTABS00011 The present invention involves a method for early detection of developing tamoxifen resistance in breast cancer. Tamoxifen is the drug of choice for hormonal therapy of a first recurrence of breast cancer, but its use is associated eventually with emergence of resistant tumors. Whereas initial treatment is usually followed by tumor regression, resistant tumors may actually resume growth under continued tamoxifen treatment. Because such growth may actually be augmented by the tamoxifen, it is essential to identify the onset of resistance as early as possible so alternative therapy may be promptly instituted. Monitoring increased levels of estrogenic tamoxifen isomers or estrogenic tamoxifen metabolites signals developing resistance.

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