Oomycete ftsz-mt as a target for antimicrobial-specific...

Details Oomycete ftsz-mt as a target for antimicrobial-specific... Oomycete ftsz-mt as a target for antimicrobial-specific...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/37 (2006.01) C12P 21/00 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2435910

The invention relates to a genes from an oomycete that encode homologs of an FtsZ protein. The invention includes methods of using these proteins to discover new antimicrobials, based on the essentiality of the gene for normal growth and development. The invention can also be used in screening assays to identify inhibitors that are potential antimicrobials. These antimicrobials may be used in a method of controlling oomycete growth on crop plants and seeds.

L'invention concerne un gène, isolé à partir d'un oomycète, codant pour des homologues d'une protéine FtsZ. L'invention concerne par ailleurs des procédés d'utilisation de ces protéines pour découvrir de nouveaux agents antimicrobiens, en se basant sur le caractère essentiel du gène dans la croissance et le développement normaux. L'invention peut également être mise en application dans des méthodes de criblage pour identifier des inhibiteurs constituant des agents antimicrobiens potentiels. Ces agents antimicrobiens peuvent être utilisés dans une méthode visant à contrôler la croissance d'oomycètes sur des cultures et des semences.

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