A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/40 (2006.01) A61K 9/00 (2006.01) A61K 31/422 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/554 (2006.01) A61K 31/724 (2006.01) A61K 47/18 (2006.01) A61K 47/48 (2006.01) A61P 27/02 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2477049
There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising (a) an antibiotic antibiotic drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration, (b) as a solubilizing agent, a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration, and (c) as a preservative, cetyl pyridium chloride. The composition is particularly useful for the treatment and/or prevention of eye infections due to gram positive bacteria.
L'invention concerne une composition pharmaceutique apte à une administration locale à un oeil, la composition contenant (a) un médicament antibiotique, par exemple le linezolid, en une concentration médicamenteuse efficace thérapeutiquement ou prophylactiquement, (b) un agent solubilisant, un composé de cyclodextrine pharmaceutiquement acceptable en une concentration suffisante pour maintenir le médicament en solution à une telle concentration médicamenteuse, et (c) en tant que conservateur, du chlorure de cétylpyridinium. La composition est particulièrement utile dans le traitement et/ou la prévention d'infections oculaires dues à des bactéries à gram positif.
Bandyopadhyay Paramita
Hassan Syed
Singh Satish K.
Bandyopadhyay Paramita
Hassan Syed
Osler Hoskin & Harcourt Llp
Pharmacia Corporation
Singh Satish K.
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