Ophthalmic biomaterials and preparation thereof

C - Chemistry – Metallurgy – 08 – L

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C08L 83/04 (2006.01) G02B 1/04 (2006.01)

Patent

CA 2527716

Composite interpenetrating network (IPN) of PDMS and PNIPAAM was formed to generate polymers with oxygen and glucose permeability as well as improved wettability compared to PDMS homopolymers and greater mechanical strength than PNIPAAM homopolymers. Transparent vinyl and hydroxyl terminated PDMS / PNIPAAM IPNs (PDMS-V and PDMS-OH IPNs respectively) were successfully synthesized. Transmission electron microscopy images verified the structure of the IPNs. Surface analysis suggested that PNIPAAM was present on the surface as well as in the bulk material. PDMS-OH IPNs generated from a PDMS-OH matrix cured in the presence of solvent had the highest glucose permeability at 10-7 cm2/s, comparable to that of the native cornea. The LCST phenomenon remained in these materials, although changes were not as abrupt as with pure PNIPAAM. These results suggest that these materials may be further developed as ophthalmic biomaterials or for controlled drug release applications.

L'invention concerne un réseau d'interpénétration composite (IPN) de PDMS et de PNIPAAM formé pour générer des polymères présentant une perméabilité à l'oxygène et au glucose, ainsi qu'une mouillabilité accrue par rapport à celle d'homopolymères PDMS, et qu'une résistance mécanique supérieure à celle d'homopolymères PNIPAAM. Des IPN PDMS / PNIPAAM en vinyle transparent et à terminaison hydroxyle (respectivement IPN PDMS-V et PDMS-OH) sont synthétisés. Des images de microscopie électronique de transmission vérifient la structure des IPN. Une analyse de surface suggère que PNIPAAM est présent sur la surface ainsi que dans la masse du matériau. Des IPN PDMS-OH générés à partir d'une matrice PDMS-OH durcie en présence d'un solvant présentent la perméabilité en glucose la plus élevée: 10?-7¿ cm?2¿/s, cette perméabilité étant comparable à celle de la cornée native. Le phénomène LCST demeure dans ces matériaux, bien que des changements ne soient pas aussi radicaux avec du PNIPAAM pur. Les résultats suggèrent que ces matériaux peuvent être développés plus avant, en tant que biomatériaux ophtalmiques ou pour des applications de libération de médicaments contrôlée.

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