Ophthalmic composition

A - Human Necessities – 61 – K

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Details

A61K 31/505 (2006.01) A61K 31/00 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2318516

The ophthalmic composition of this invention is used for treatment of diabetic corneal lesion and/or for treatment of deteriorated corneal esthesia, which comprises, as an active ingredient, a compound represented by general formula (I): wherein A and B are independently lower alkylene, X, Y, and Z are independently halogen, or a pharmacologically acceptable salt thereof. In addition, the ophthalmic composition of this invention is used for treatment of non-diabetic corneal lesion, for treatment of dry eye syndrome, and/or for treatment of hypolacrimation which comprises, as an active ingredient, an aldose reductase inhibitor. The ophthalmic compositions of this invention are effective for treatment of at least one disease selected among corneal lesion, deteriorated corneal esthesia, dry eye syndrome, and hypolacrimation.

La composition ophtalmique de l'invention est utilisée dans le traitement des lésions cornéennes d'origine diabétique et/ou des lésions qui perturbent la sensibilité cornéenne. Cette composition comprend, comme ingrédient actif, un composé représenté par la formule générale (I) dans laquelle A et B représentent indépendamment alkylène inférieur; X, Y et Z représentent indépendamment halogène, ou un sel pharmaceutiquement acceptable. Cette composition ophtalmique est également utilisée dans le traitement des lésions cornéennes d'origine non diabétique, du syndrome des yeux secs, et/ou de la diminution de la production lacrymale, et comprend, comme ingrédient actif, un inhibiteur d'aldose réductase. Les compositions ophtalmiques de cette invention sont efficaces dans le traitement d'au moins une maladie sélectionnée parmi les lésions cornéennes, les lésions qui perturbent la sensibilité cornéenne, le syndrome des yeux secs et la diminution de la production lacrymale.

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