A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/209, 167/268
A61K 31/475 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01)
Patent
CA 1139668
ABSTRACT The invention relates to a method for temporarily alleviat- ing the symptoms of glaucoma. Conventional therapy for glaucoma is with pilocarpine and/or epinephrine administered topically several times daily. One of the problems with many conventional drugs for the treatment of glaucoma is that they decrease the size of the pupil, i.e., they are miotic drugs. This is an undesirable side effect, resulting in temporarily impaired vision. The present in- vention minimizes these difficulties by providing a method of re- ducing IOP and for treating glaucoma in which there is a minimum of miotic side effects. The present invention relates to a thera- peutic composition comprising a topically administrable ophthalmic pharmaceutical carrier and an effective amount of an alkaloid selected from colchicine or vinblastine. The present invention also relates to a method for reducing intraocular pressure and for temporarily alleviating the symptoms of glaucoma in humans comprising topically administering to the eyes of a human, having increased intraocular pressure or having glaucoma an effective amount of the foregoing composition.
327076
Bhattacherjee Parimal
Eakins Kenneth E.
Gowling Lafleur Henderson Llp
Nelson Research & Development Company
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